A multivariate Cox regression analysis also showed that CHIP significantly increased the risk of new-onset type 2 diabetes in the hyperLDLC group (adjusted HR 1.64, 95% CI 1.09–2.47, p = 0.018) but not in the non-hyperLDLC group (adjusted HR 0.98, 95% CI 0.69–1.38, p = 0.894) (Figure 1D). This evidence concerns the gene STUB1 and type 2 diabetes mellitus.