Increase in ATP‐binding cassette subfamily A member 1 (ABCA1), ATP‐binding cassette subfamily A member 2 (ABCA2), apolipoprotein E (Apo E), lecithin‐cholesterol acyltransferase (LCAT), cytochrome P450 family 7 subfamilies A member 1(CYP7A1) fight against atherosclerosis induced by consumption of high‐fat diet (Narasimhulu et al., 2015). The gene discussed is CYP7A1; the disease is atherosclerosis.