IRS1 and metabolic dysfunction-associated steatotic liver disease: Also, it attenuated the expression of p‐JNK1/2/3, phospho‐NF‐κB p65, phospho‐insulin receptor substrate 1 (IRS1), phospho‐IKK α/β, and elevated the level of x‐box‐binding protein 1 (XBP1), GSH, vitamin C, Nrf2, SOD, CAT, and GPx in nonalcoholic fatty liver disease in fructose‐fed mice (Yang et al., 2018).