In addition, it has been shown that the consumption of aqueous extract of sesame oil (50 and 250 μg/mL) has antiinflammatory effects by down‐regulating the expression of inflammatory proteins and reduces TNF‐α, IL‐6, MCP‐1, and vascular cell adhesion molecule 1 (VCAM1) in low‐density lipoprotein receptor knockout (LDLR−/−) mice with atherosclerosis induced by high‐fat diet (Narasimhulu et al., 2018). This evidence concerns the gene TNF and atherosclerosis.