Moreover, IP injection of ethanol extract of sesame seed (300 mg/kg) reduced the amount of inflammatory cytokines against ischemia induced by endothelin‐1 (ET‐1) in rats (Botelho et al., 2014) Oral administration of sesamin (100 mg/kg) reduced ALT, AST, total bilirubin (TBIL), IL‐6, cyclooxygenase −2 (COX‐2), and inhibited NF‐kB elevated by carbon tetrachloride (CCl4) in rats (Chen et al., 2015). Here, PTGS2 is linked to ischemia.