Owing to their unique genomic features, biological behavior and poor clinical prognosis, the subtypes of DLBCL, formerly known as double-hit (DHL) and triple-hit (THL) lymphomas, were classified in 2016 as a new category, termed “high-grade B-cell lymphoma” (HGBL), with translocations involving MYC and B-Cell Lymphoma 2 (BCL2) and/or B-Cell Lymphoma 6 (BCL6). This evidence concerns the gene MYC and B-cell non-Hodgkin lymphoma.