In terms of mutational and gene expression profiles, DLBCL/HGBL MYC/BCL2 exhibit a mutational signature closer to that of follicular lymphoma (FL), including Cyclic adenosine monophosphate Response Element Binding Protein (CREBBP), BCL2, Lysine Methyltransferase 2D (KMT2D), MYC, Enhancer of Zeste Homolog 2 (EZH2) and Forkhead box protein O1(FOXO1), while showing a gene expression profile similar to centroblasts of the germinal center (GC) dark zone. Here, FOXO1 is linked to diffuse large B-cell lymphoma.