Complementarily, ICC considers double-hit (DH)-HGBL to comprise two entities: HGBL with MYC and BCL2 rearrangements, with or without BCL6 rearrangement (HGBL-DH-BCL2), and a provisional entity, HGBL-DH-BCL6, with MYC and BCL6 rearrangements[7]. This evidence concerns the gene MYC and intrahepatic cholangiocarcinoma.