In contrast, HGBL-DH-BCL6 less frequently shows a Germinal center B cell-like (GCB) immunophenotype, is cytogenetically less complex and exhibits impairment of E2F targets, but not of the TP53 and MYC signaling pathway, characteristic of DLBCL/HGBL MYC/BCL2[5,7]. The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.