CRP and colitis: In patients with extensive colitis, the AUC of CRP, FC, IL-6, FDP, GSP and α1-MG independently predicted MES 3 is 0.70, 0.65, 0.70, 0.73, 0.76, and 0.70, respectively, and the AUC of IL-6 + GSP+ α1-MG predicted MES3 can reach 0.82, with sensitivity and specificity of 66% and 94%, respectively (Figures 1B, C).