In patients with distal ulcerative colitis, the AUC of CRP, FC, D-D, FDP, and α2-MG independently predicted MES 3 is 0.70, 0.68, 0.77, 0.69, and 0.76, respectively, and the AUC of CRP + D-D + α2-MG for predicting distal colitis MES 3 was 0.85, with a sensitivity and specificity of 61% and 96%, respectively. The gene discussed is CRP; the disease is distal colitis.