Cytokinesis failure, characteristic of some microcephaly models (Di Cunto et al., 2000; Higgins et al., 2010; Harding et al., 2016; Perez et al., 2019; Reilly et al., 2019; Tedeschi et al., 2020; Little et al., 2021) has been reported to stabilize TP53 by engaging the Hippo pathway (Ganem et al., 2014). Here, TP53 is linked to microcephaly.