VPS13D and cerebellar ataxia: With this optimized tool, we have created a model to investigate the progressive neurological and locomotor defects associated with Vps13D perturbation in fly neurons, better modeling the clinical ataxia phenotype described in patients with mutations in VPS13D (Gauthier et al., 2018; Seong et al., 2018; Koh et al., 2020; Pauly et al., 2023).