Previous studies have identified that age, surgical treatment of the primary tumour, KPS, extracerebral metastasis, targeted therapy, NSE level, ALP level, and PLR are factors that influence the prognosis of NSCLC patients with BM (Rodrigus, de Brouwer & Raaymakers, 2001; Sanchez de Cos et al., 2009; Fuchs et al., 2021; Junger et al., 2021; Yu et al., 2021; Jacot et al., 2001; Cho et al., 2021). Here, ENO2 is linked to neoplasm.