To reveal how the HIF-1-α/VEGFA signaling pathway affects hemangioma proliferation, migration, and angiogenesis, We tested the expression of HIF-1-α, phospho-Akt, Akt, phospho-Erk, Erk, and VEGFA on protein levels in HUVECs and HemECs using Western Blot. The gene discussed is AKT1; the disease is hemangioma.