Among the Atf6Δhep mice, PPM1H-Atf6Δhep mice apparently had a reduced number of induced tumor nodules and ratio of liver weight to body weight compared with NC-Atf6Δhep mice, while only a small difference between PPM1H-Atf6fl/fl and PPM1H-Atf6Δhep mice (Figures 5F and 5G), demonstrating that ATF6 promotes progression of HCC through regulation of PPM1H. Here, ATF6 is linked to neoplasm.