As shown in Figures 5A and S7A, knockdown of PPM1H obviously enhanced the tumorigenicity and tumor growth of Hep 3B2.1-7 cells, while PPM1H overexpression in Hep 3B2.1-7 cells formed smaller xenogeneic tumors than in the control group (Figures 5A and S7A). The gene discussed is PPM1H; the disease is neoplasm.