INS and Hyperglycemia: Moreover, the impairment in the hepatic insulin signaling culminates in gluconeogenesis increases, which contributes to hyperglycemia, and induces hepatic lipid synthesis, exacerbating steatosis and hypertriglyceridemia (Shlomai et al., 2012; Gurzov et al., 2014; Fang et al., 2020; Joseph et al., 2020).