The involvement of NaV1.6 in apoptosis-related signaling has been also reported in Follicular Thyroid Carcinoma (FTC), where the apoptosis of FTC-133 cells was enhanced upon treatment with ubenimex (an antineoplastic drug that promotes tumor cell apoptosis), and, when combined with a siRNA against NaV1.6, an enhanced effect was observed. Here, SCN8A is linked to thyroid cancer, nonmedullary, 2.