In 2016, Xia and colleagues reported the aberrant NaV1.7 expression in gastric cancer tissue samples and two gastric cancer cell lines, where the downregulation of the sodium channel by siRNAs ultimately decreased the NHE-1 expression and activity via p38 activation and the oncoprotein metastasis-associated in colon cancer-1 (MACC1) downregulation, generating an increased extracellular pH, decreased intracellular pH, reduced invasion, and less proliferation of the cells. This evidence concerns the gene MACC1 and gastric cancer.