NHE-1 is upregulated in different types of cancer and plays a fundamental role in malignant invasion by altering the metabolic environment and cell invasiveness, including the activation of matrix metalloproteinases (Gillet et al., 2009; Lin et al., 2011; Lin et al., 2012; Litan and Langhans, 2015). The gene discussed is SLC9A1; the disease is cancer.