SCN5A and astrocytoma (excluding glioblastoma): The same modulating effect can be seen using siRNAs to downregulate the expression of NaV1.5 in U251 astrocytoma cells (Xing et al., 2014), although in other cases, the transwell migration is not affected by the downregulation of VGSCs (Roger et al., 2007; Carrithers et al., 2009; Hernandez-Plata et al., 2012).