PIM1 and lung carcinoma: An experiment by Han et al. also demonstrated the inhibitory effect of the miR-370 signaling pathway on lung cancer via downregulating PIM1. Moreover, icariin inhibited proliferation and induced apoptosis in A549 and H358 lung cancer cells, which was associated with the activated miR-370 signaling pathway and downregulation of PIM1 (Han, 2017).