It can not only inhibit the IGFBP2/AKT/BCL-2 pathway and activate the P53 signaling pathway to participate in XN-induced GBM cell apoptosis (Chen et al., 2016), but it also induces apoptosis of glial pathway cells by increasing ROS and activating MAPK pathways (Festa et al., 2011). The gene discussed is AKT1; the disease is glioblastoma.