AKT1 and glioblastoma: Zheng et al. have shown that SW33 can induce autophagy through the PI3K/AKT/MTOR and AMPK/MTOR signaling pathways in patients with GBM, thus playing an anti-GBM role, significantly inhibiting tumorigenesis, without having obvious adverse effects on the body (Zheng et al., 2021).