It can not only inhibit the IGFBP2/AKT/BCL-2 pathway and activate the P53 signaling pathway to participate in XN-induced GBM cell apoptosis (Chen et al., 2016), but it also induces apoptosis of glial pathway cells by increasing ROS and activating MAPK pathways (Festa et al., 2011). This evidence concerns the gene BCL2 and glioblastoma.