In hepatocellular carcinoma, silibinin has been found to effectively abate hepatocarcinogenesis and hepatocellular carcinoma growth by regulating various signaling pathways including HGF/c-Met, Wnt/β-catenin and PI3K/Akt/mTOR(Yassin et al., 2022). Here, HGF is linked to hepatocellular carcinoma.