On the other hand, non-viral transfection with star polymers can be used as a potential therapeutic solution for OI patients mainly due to their chemical structure, as well as molecular weight in relation to their effect on cytotoxicity (Bekhite and Schulze, 2021).Thus, in this work, we assessed the possibility of repairing two mutations in the COL1A1 gene in patient-derived cells after their reprogramming to iPSCs. This evidence concerns the gene COL1A1 and osteogenesis imperfecta.