Pancreatic TME (2) constitutes a complex interaction between tumor cells, stromal cells such as cancer-associated fibroblasts (CAFs), endothelial cells, perivascular cells, immune cells such as tumor-infiltrating lymphocytes (TILs), tumor-associated macrophages (TAMs), and extracellular matrix elements such as collagen (3, 4), hyaluronic acid (5, 6), fibronectin (7–9), laminin (10–14), and sulfated glycosaminoglycans (15) in an acidic pH (16), resulting in a heavy stromal desmoplastic reaction. This evidence concerns the gene FN1 and neoplasm.