identified numerous candidate targets with a miRNA–mRNA network with high connectivity contained 13 hub mRNAs and five hub exosomal miRNAs (mRNA: CBFB, CDH3, ETV4, FUT1, FOXQ1, GRIN2D, GCNT2, KIAA1549, KRT80, LZTS1, SPTBN2, SLC39A10, ZSWIM4; and exosomal miRNA: hsa-miR-29c, hsa-miR-126, hsa-miR-139, hsa-miR-141, and hsa-miR-423) as potential biomarkers with high diagnosis value for CRC. Here, SPTBN2 is linked to colorectal carcinoma.