• SChLAP1 expression was significantly higher in the PCa group than in the controls (AUC = 0.8697).• The AUC of the combination of SAP30L-AS1 and SChLAP1 was 0.9224.• AUC for SChLAP1 combined with PSA was 0.9516. Here, SCHLAP1 is linked to posterior cortical atrophy.