Multivariable logistic regression showed that AFP > 20ng/mL (p=0.022, OR=3.863, 95%CI: 1.218 ~12.245), NLR > 2.25 (p=0.005, OR=9.159, 95%CI: 1.962 ~ 42.753), non-smooth tumor margin (p=0.013, OR=4.776, 95%CI: 1.393 ~ 16.374), TLRHBP ≤ 0.6 (p=0.003, OR=6.993, 95%CI: 1.962 ~ 24.927) and T1HBP >705 msec (p<0.001, OR=10.673, 95%CI: 2.614 ~ 43.583) were independent predictors of high Ki-67 LI in HCC tumors (Table 3, Figure 2). This evidence concerns the gene AFP and neoplasm.