MKI67 and neoplasm: The reason why HCCs with higher Ki-67 LI tend to demonstrate lower relative tumoral SI probably is that normal hepatocytes gradually turn into actively proliferated and uncontrolled malignant tumor cells with higher Ki-67 LI during multistep hepatocarcinogenesis, while at the same time, the expression of organic anion transporting polypeptide (OATP) usually decreased, hence resulting in less uptake of gadoxetic acid (34, 35).