Furthermore, our analysis using CancerDR database (32) revealed significant association between MNAI and many molecular targets, indicating it as a potential biomarker for predicting the response to more cancer treatment targets besides PD-1 and CTLA-4 (Supplementary Figure 8 lower pane, spearman correlation |R|>0.3 and p value< 0.05). This evidence concerns the gene CTLA4 and cancer.