The present meta-analysis evaluated the relationship between <i>tumor necrosis factor-alpha</i> (<i>TNF-α</i>) polymorphisms (<i>rs361525</i>, <i>rs1800629</i>, <i>rs1799724</i>, <i>1800630</i>, and <i>rs1799964</i>) and psoriasis risk in studies following Hardy-Weinberg equilibrium (HWE).<h4>Materials and methods</h4>Four databases were searched to retrieve relevant studies reporting the distributions of <i>TNF-α</i> polymorphisms in psoriasis cases compared to controls. Here, TNF is linked to psoriasis.