Furthermore, GFAP-immuno-positive area was significantly reduced in 9-month-old APPKI-SRRKO mice compared with age-matched APPKI mice (p < 0.001, Supplementary Figure 4), suggesting that endogenous D-serine can also affect astrogliosis and neuroinflammation during the amyloid pathology in APPKI mice. The gene discussed is GFAP; the disease is amyloidosis.