Furthermore, adipokine expression and secretion were investigated <i>in vitro</i> using differentiated human primary ABD and FEM subcutaneous adipocytes derived from the study participants.<h4>Results</h4>Plasma leptin and plasminogen activator inhibitor (PAI)-1 concentrations were higher, and ABD and FEM adipocytes were larger in women with obesity than normal weight. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.