found that the H3K4 trimethylation (H3K4me3) level declined in PTIP knockout mouse podocytes, which may affect the transcription of the neurotrophic tyrosine kinase receptor type 3 (Ntrk3) gene, resulting in podocyte development disorder and abnormal podocyte arrangement and eventually leading to tubulointerstitial fibrosis and glomerulosclerosis (88, 89). This evidence concerns the gene NTRK3 and glomerulosclerosis.