The N-glycosylation profile of CEA purified from human colon carcinoma cells and from human liver metastases of CRC cells was analyzed by MS, showing distinctive features versus normal CEA N-glycosylation pattern, namely simultaneously increased bisection and branching, incomplete galactosylation or poly-LacNAc elongation on highly branched structures, moderate levels of sialylation and high levels of fucosylation (Figure 1) [53]. The gene discussed is CEACAM5; the disease is colon carcinoma.