The AFP-L3 percentage of the total AFP (AFP-L3%), calculated as [(AFP-L3/total AFP) × 100], has been used as a marker for early diagnosis of HCC, for therapy evaluation and to predict the prognosis of HCC [26, 32, 33], being particularly useful in the “diagnostic dilemma” of cases with total AFP concentrations between 10 ng/mL and 200 ng/mL and to exclude HCC in benign conditions with elevated AFP [27, 34]. Here, AFP is linked to hepatocellular carcinoma.