Tian et al. have reported that tissue factor expression in colon cancer cell lines including DLD‐1 is correlated with their invasive ability and TF knockdown in LoVo colon cancer cells reduces invasion/migration in vitro and hepatic metastasis in vivo through downregulation of matrix metalloproteinases MMP2 and MMP9.42 This evidence concerns the gene MMP9 and colonic neoplasm.