The VM-associated anticoagulant42 and SCLC brain metastasis colonization factor55SERPINE1, the angiogenesis-associated AXL receptor tyrosine kinase,56 master-regulator of VM FOXC246 and endothelial-associated genes57 were all significantly up-regulated in non-NE compared with NE cells (Fig. 4H and I). This evidence concerns the gene NTRK1 and small cell lung carcinoma.