Co-operation between non-NE and NE cells is essential for metastasis in the RP (Trp53fl/fl/Rb1fl/fl) SCLC GEMM13 and VM is required for metastasis in a breast cancer model.17 Studies to evaluate relationships between VM, MYC, NOTCH, and metastasis in SCLC CDX are underway. This evidence concerns the gene MYC and breast carcinoma.