INS and Hypoglycemia: Increased insulin action can be demonstrated by increased glucose requirement (e.g., >8 mg/kg/min in a neonate normal 4–6 mg/kg/mi [4]), inappropriately suppressed plasma concentrations of FFA and BOHB during hypoglycemia, and an inappropriate glycemic response to glucagon at a time of hypoglycemia (Table 1) [5–7].