Unlike similar studies that did not review the dosing regimen used, nor its effect on the studied endpoints, the present systematic review suggests that the fastest dose-dependent effect was exerted by cells cryopreserved at the primary site of infection [27] and the high dose showed not only a greater decrease in these parameters but also a low expression of αSMA and reversal of induced histopathological changes [26,43,44]. This evidence concerns the gene ACTA1 and infection.