Current publicly available RNA and protein datasets from cancer patients treated with different ICT in tandem with cutting-edge genomic and bioinformatic tools could hold provide important information on these deficits and uncover new tumour desertification biomarkers, potentially driving advancements in precision medicine, facilitating the rational design of new therapeutic strategies aimed at restoring CIITA and HLA-DM associated networks, boosting tumour immunogenicity. Here, HLA-DMA is linked to cancer.