For example, specific M2 macrophage transcriptomic signatures associated with stabilin-1 (STAB1) have been described to predict resistance to ICT in cold tumours of the Pancreatic Cancer Action Network (PanCAN)-GDC-TCGA study in a T-cell dysfunction manner, meaning that T-cell dysfunction, rather than T-cell trafficking, could be triggered by specific macrophage gene expression programme that impacts T cells functions and their levels within ICT-treated tumours [31]. The gene discussed is STAB1; the disease is neoplasm.