Therefore, the first conditional rule for ICT response is the successful MHC-dependent presentation of tumour antigen in the format of peptides to T-cell receptors (TCR), which results in the generation of a clonally expanded population of anti-tumour effector lymphocytes, as shown in the wheel diagram of Fig. 1 (orange, Stages 1–3). This evidence concerns the gene HLA-C and neoplasm.