Likewise, P53 expression, with an approximate molecular weight of 44 kDa, was markedly increased by kunitz4-a and kunitz4-c in HT29 and HepG2 cell lines, suggesting that both kunitz4-a and kunitz4-c could increase the intracellular expression level of the tumor suppressor P53 gene in tumor cells. This evidence concerns the gene TP53 and neoplasm.