UCHL1 and Alzheimer disease: In this work, we focused on measuring the activity of pyruvate kinase isoform M (PKM) and aldolase (ALDO) two glycolytic enzymes that have been consistently found increased in AD CSF [13], together with the levels of ubiquitin C-terminal hydrolase L1 (UCH-L1), and fatty acid-binding protein 3 (FABP3), two proteins involved respectively in protein processing [14] and lipid metabolism [15], also found to be increased in AD CSF in large scale proteomic studies [9, 10].