PHF8 and neoplasm: Moreover, the immunofluorescence density of granzyme B+ (GZMB+) and interferon-γ+ (IFN-γ+) CD8+ T cells also significantly increased in Phf8-deficient CT26 tumors (Fig. 1m), implying that depletion of tumor PHF8 promotes adaptive anti-tumor CD8+T cell immune responses and results in tumor growth repression.