For example, the DNA methyltransferase DNMT6, the histone methyltransferase EZH27, the histone chaperone ASF1A8, the H3K9 methyltransferase SETDB19 and the lysine-specific demethylases 1 A (LSD1)10 and 5B (KDM5B)11 have been reported to regulate anti-tumor immunity through different mechanisms. The gene discussed is KDM1A; the disease is neoplasm.