To this end, we analyzed strand-specific RNA-seq data and found that the expression of a cluster of retrotransposons was regulated by tumor PHF8 (Fig. 4a, b, Supplementary Fig. 4a and Supplementary Data 7, 8), including long terminal repeat (LTR)-containing ERVs and non-LTR elements, such as long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs) (Supplementary Fig. 4b, c). Here, PHF8 is linked to neoplasm.