Diacerein administration to BDL rats in our study showed a reduction in hepatic levels of caspase 3 and BAX immunostaining, indicating an anti-apoptotic effect of diacerein in cholestatic liver fibrosis, which comes with other data reported by Elshal and Abdelmageed71 and Bu et al.72. The gene discussed is BAX; the disease is Hepatic fibrosis.