Another example is that EGFR gene and protein level expressions are associated with prognosis in the glioblastomas (grade IV glioma), and even in the lower grade gliomas (grade II-III), EGFR protein level expression is associated better prognosis with the IDHwt molecular subtype which is the high-risk subtype compared to IDHmut. The gene discussed is EGFR; the disease is central nervous system cancer.