Finally, as we have shown previously and reinforce here, both the production of amyloids and the antiviral activity of APP can be simultaneously harnessed using clinically approved γ-secretase inhibitors, suggesting that these drugs may be more beneficial in the treatment of HAND than they have proven to date in the treatment of non-HIV-related neurodegenerative conditions such as Alzheimer’s Disease. The gene discussed is APP; the disease is HIV-associated neurocognitive disorder.