RUNX2 and osteosarcoma: Runx2, as a member of the RUNX family, is highly expressed in bone tissue and is a highly active molecule in the development, differentiation, and maturation of bone tissue, as well as the occurrence and development of various tumors (Li et al. 2012).Some studies have shown that the RUNX2 DNA copy number, RNA and protein levels in Osteosarcoma are highly elevated (Martin et al. 2011).