Indeed, ECM activated ERK and PI3K/Akt signaling in cancer cells and reduced sensitivity to cisplatin, fluorouracil and epirubicin, and the reduction in the level of collagen type I and fibronectin in ECM resulted in diminished colony formation of cancer cells and sensitization to cisplatin (Senthebane et al. 2018). The gene discussed is AKT1; the disease is cancer.