We examined the association of variants with a minor allele frequency (MAF) of <0.001 in 22 moderate- to high-penetrance CRC genes.2 For the recessive CRC genes MUTYH, NTHL1, MSH3, and MBD4, we assessed the risk of CRC associated with biallelic or monoallelic carriers. The gene discussed is NTHL1; the disease is colorectal carcinoma.