Biallelic carriers of MUTYH c.1187G>A:p.Gly396Asp (OR, 32.1; P = 1.41 × 10–6) or c.536A>G:p.Tyr179Cys (OR, 16.1; P = 0.02) and compound heterozygote carriers of these 2 variants had a substantially increased CRC risk (OR, 58.03; P = 4.2 × 10–4) (Table 1). This evidence concerns the gene MUTYH and colorectal carcinoma.