HNF4A and acute lymphoblastic leukemia: THY1 protein expression was increased in Adh ALL cells (Figure 6I), and the CD90-positive subpopulation of Adh NALM6-TCF/LEF cells displayed elevated β-catenin-mediated transcriptional activity (Figures 6I and 6J) demonstrating that the hybrid cluster is dependent upon on WNT/β-catenin-mediated transcriptional activity.