Indeed, we discovered that β-catenin-mediated transcriptional activity is increased in hybrid ALL cells exhibiting THY1 expression, and specific inhibition of the β-catenin-CBP complex, which is known to promote self-renewal, diminished the survival and drug resistance of PDX ALL cells adhered to MSCs ex vivo and reduced leukemic burden of NALM6 xenograft model in vivo. The gene discussed is THY1; the disease is acute lymphoblastic leukemia.