TGFB1 and acute lymphoblastic leukemia: The adhesome is a network comprised of interactions between cellular receptors and components, and TGFβ is known to regulate cell-matrix and cell-cell adhesions.36 Thus, to systematically identify cell adhesion genes implicated in adhesion of ALL to MSCs, we performed a CRISPR-Cas9 screen targeting adhesome37,38 and TGFβ pathway genes39 (Table S5) (Figures 3A, S2A, and S2B).