AXIN1 and leukemia: Our findings are consistent with prior data showing that the inhibition of the WNT/β-catenin pathway sensitized leukemic cell lines co-cultured with stromal cell lines and improved overall survival in a mouse model of leukemia cell line, but high concentrations of XAV-939, a stimulator of β-catenin degradation by stabilization of Axin, were required.62