HNF4A and acute lymphoblastic leukemia: The canonical WNT/β-catenin signaling pathway involves the nuclear translocation of β-catenin and activation of target genes via TCF/LEF TFs in response to WNT ligands.53 Accumulation of β-catenin in Adh ALL cells and inhibition of its interaction with TCF reduced cell viability, indicating that increased β-catenin forms a complex with TCF/LEF, leading to transcription activation in Adh ALL cells.