Enriched genes in Adh ALL patient samples included the EMT transcription factors (TFs) SNAI2 and TWIST1, the cadherins CDH2 and CDH11, collagens COL1A1 and COL3A1, FN1 (fibronectin), ACTA2 (actin), and MMP2 genes (Figure 4C). This evidence concerns the gene TWIST1 and acute lymphoblastic leukemia.