Various cells in the BME secrete IL6, leading to activation of STAT3 signaling in tumor cells55; moreover, we observed enrichment of IL6 in co-culture media due to secretion from MSCs (Figures 2B and 2C) that demonstrated that IL6 secreted from MSCs led to transient activation of STAT3 signaling in Adh ALL cells. This evidence concerns the gene IL6 and acute lymphoblastic leukemia.