Antiphospholipid syndrome (APS) is a hypercoagulable disorder characterized by the persistent presence in the blood of antiphospholipid antibodies (aPL) which include lupus anticoagulant (LAC) positivity and/or medium–high levels of anticardiolipin (aCL) and/or anti-beta2-glycoprotein I (anti-β2GPI) antibodies in patients with venous, arterial or micro vessels thrombosis and/or pregnancy morbidity [1]. The gene discussed is LCT; the disease is autoimmune polyendocrinopathy.