PrPC, as well as other amyloidogenic proteins, such as amyloid beta peptide (Aβ), tau and α-synuclein, all associated with neurodegenerative diseases, may undergo conformational transitions, during which the content in β-sheet structures increases, and form amyloid oligomers, which are able to grow via interactions between the same regions of protein molecules generating protofibrils [100]. This evidence concerns the gene PRNP and neurodegenerative disease.