Certainly, control of ciliation would not be the only way in which KRAS could affect IPA and lipid droplet abundance; for example, one recent study has shown that expression of KRAS in acinar cells reduces expression of FGF21, a metabolic regulator that reduces obesity, and that treatment of KRASG12D/+ mice maintained on a high fat diet with recombinant FGF21 reduced pancreatic triglyceride levels, inflammation, and tumorigenesis [44]. This evidence concerns the gene FGF21 and obesity due to melanocortin 4 receptor deficiency.