Notably, these activities did not reflect loss of kinase activity and control of NF-κB, but rather kinase independent role of IKKα in regulating autophagic degradation; simultaneous ablation of p62 in mice with pancreatic knockout of IKKα showed reduced signs of oxidative and ER stress, and had reduced symptoms of pancreatitis; parallel examination of human pancreatitis specimens suggested many were characterized by downregulation of IKKα and elevated p62, implying clinical relevance of the findings [168]. The gene discussed is NFKB1; the disease is pancreatitis.