To investigate whether ANGPTL2 activity impacts MHC‐I expression in human cancer cells, we performed siRNA‐mediated ANGPTL2 knockdown (KD) in the human tRCC cell line UOK120, which was established from tumors of a tRCC patient [12] (Fig. 5A,B). This evidence concerns the gene ANGPTL2 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.