Given that downregulation of the antigen presentation pathway and a reduction in IFNγ sensitivity in tumor cells facilitate evasion of anti‐tumor immunity [8, 9, 10], we hypothesized that tumor cell ANGPTL2 expression regulates these pathways in a way that attenuates CD8+ T‐cell‐mediated anti‐tumor immune responses. This evidence concerns the gene ANGPTL2 and neoplasm.