Although expression levels of H2‐K1 and H2‐D1 mRNAs in Angptl2 KO and Itga5 KO cells were equally increased relative to controls in the presence of IFNγ, the extent of increase in cell surface H‐2Db expression was markedly less than that of H‐2Kb, suggesting that H‐2Db expression is regulated post‐transcriptionally in tRCC cells. This evidence concerns the gene ITGA5 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.