CD8+ cytotoxic T cells recognize tumor cells displaying tumor antigens bound to major histocompatibility complex class I (MHC‐I)/human leucocyte antigen (HLA) proteins and kill tumor cells by producing cytotoxic effector molecules, such as granzyme B and tumor necrosis factor α (TNFα) [1, 2, 3]. This evidence concerns the gene GZMB and neoplasm.