ITGA5 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions: Importantly, we showed a significant decrease in H3K27me3 levels and EZH2 occupancy at promoters of antigen presentation‐related genes in Angptl2 KO and Itgα5 KO tRCC cells relative to controls, suggesting attenuation of JARID2‐mediated recruitment and/or activation of the PRC2 complex in these KO cells.