We also established a tRCC mouse model in which the PRCC‐TFE3 fusion gene is constitutively expressed in renal tubular epithelial cells [18, 19] and demonstrated that tumor cell‐derived ANGPTL2 is tumor‐promoting, whereas tumor stroma‐derived ANGPTL2 suppresses tumor progression by enhancing dendritic cell activation and subsequent CD8+ T‐cell‐mediated anti‐tumor immune responses [13]. The gene discussed is ANGPTL2; the disease is neoplasm.