To investigate this possibility, we established Angptl2 KO tumor lines (Angptl2 KO1 and KO2) using the primary tRCC cell line R286 established from tumors of tRCC mice [19] (Fig. 2A) and assessed expression of antigen presentation‐related genes, such as MHC‐I (H2‐K1 and H2‐D1) and antigen presentation machinery‐related molecules (B2m, Tap2, and Tapbp) (Fig. 2B). This evidence concerns the gene B2M and neoplasm.