Since IFNγ induces expression of IRF1 and NLRC5, which are key transcriptional activators of various IFNγ‐responsive genes, including MHC‐I and antigen presentation machinery‐related genes, by activating STAT1 [4, 5, 6], we hypothesized that ANGPTL2 attenuates IFNγ‐induced expression of Irf1 and Nlrc5 in tRCC cells. This evidence concerns the gene ANGPTL2 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.