To investigate this possibility, we established Angptl2 KO tumor lines (Angptl2 KO1 and KO2) using the primary tRCC cell line R286 established from tumors of tRCC mice [19] (Fig. 2A) and assessed expression of antigen presentation‐related genes, such as MHC‐I (H2‐K1 and H2‐D1) and antigen presentation machinery‐related molecules (B2m, Tap2, and Tapbp) (Fig. 2B). Here, ANGPTL2 is linked to renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.