These findings suggest that the ANGPTL2‐α5β1 integrin pathway attenuates IFNγ‐induced MHC‐I expression in tumor cells by accelerating PRC2‐mediated repressive histone modification, decreasing tumor cell susceptibility to CD8+ T‐cell‐mediated anti‐tumor immune responses (Fig. 7). The gene discussed is ANGPTL2; the disease is neoplasm.