We then used flow cytometry to examine lymphocytes infiltrating kidney tissues from tRCC and CKO tRCC mice and observed that the number of CD45+ cells infiltrating kidney tissues significantly increased in CKO tRCC compared with tRCC mice (Fig. 1D). Here, PTPRC is linked to renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.