Finally, the expression of two COAD stemness‐related markers, ALDH1A3 and c‐MYC [56, 57], was reduced in spheroids treated with GCN2i, confirming that GCN2 is essential for the viability of c‐Myc‐expressing tumor cells and the elimination of quiescent tumor cells in the presence of the drug (Fig. 2H). Here, ALDH1A3 is linked to neoplasm.