Increased TLR2 expression is associated with poor outcome, neuronal death, and the accumulation of inflammatory cells, including monocytes. TLR2 requires CD36 to initiate an inflammatory response in ischemia. TLR4 is associated with stroke severity and cytokine/ICAM‐1 levels. TLR4 can activate multiple downstream inflammatory pathways to trigger proinflammatory gene expression. The gene discussed is ICAM1; the disease is stroke disorder.