USP13 and hereditary clear cell renal cell carcinoma: For instance, USP13 was shown to be upregulated in lung cancer and ovarian cancer, and its intracellular level was associated with the progression of malignant tumors.[18, 41] In addition, USP13 was also found to be involved in renal cell carcinoma,[19] which indicated the potential relevance between USP13 and kidney disease.