LCN2 and cancer: In addition, we also observed that nilotinib caused renal tubular degeneration and expansion (black arrow), which corresponded to the upregulation of Ngal and Kim‐1, biomarkers of renal injury (Figure 1E,F).[25] In view of previous studies indicating that apoptosis is widely implicated in the nephrotoxicity of cancer chemotherapeutic drugs, we further identified the cause of cell death by TdT mediated dUTP nick end labeling (TUNEL) staining.