Gao et al. designed a cationic lipid-coated poly(lactic acid)-hydroxyacetic acid copolymer (PLGA) nanosubmarine based on the phenomenon that sorafenib to conquer drug resistance in hepatocellular carcinoma by activating the stromal-derived cytokine-1α/C-X-C motif chemokine receptor 4 (SDF1α/CXCR4) axis [351]. The gene discussed is CXCR4; the disease is hepatocellular carcinoma.