LAMB2 and neoplasm: The His6 sequence responded to the acidic tumor microenvironment and thus underwent charge and molecular conformational changes, causing the laminin mimic peptide (LMMP) molecule to change from hydrophilic to hydrophobic, mimicking the process of fibril formation by natural laminin, forming a fibrous network in the tumor vasculature, blocking the tumor vasculature and inhibiting tumor growth [359].