IL1B and infection: Ki20227 treatment significantly inhibited the expression of the proinflammatory cytokines TNF-α (P < 0.01), IL-6 (P < 0.01), and IL-1β (P < 0.05) on day 3 post-infection; however, no significant difference was observed in the expression of the Ki20227-treated and PRV-infected control groups on days 4 and 5.