MAPT and supranuclear palsy, progressive, 1: Neuronal inclusions composed of the aberrant aggregated microtubule-associated protein tau (MAPT) have been found in the brains of patients with neurodegenerative disorders called tauopathies, including AD, progressive supranuclear palsy (PSP), frontotemporal lobar degeneration (FTLD), and Pick’s disease [PiD, also termed frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)].