SLC6A3 and Denys-Drash syndrome: To further explore why H-Y stage 1 predicts the occurrence of DDS, we compared the clinical features of patients with H-Y stage 1 and stage 2 after follow-up and showed that the age, age of onset, UPDRSIII and total score, and mean uptake of caudate and putamen DAT in H-Y stage 1 were significantly lower than those in stage 2 (P < 0.05).